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In the early 1980’s, methotrexate (MTX) assumed the positioning of being the disease modifying anti-rheumatic drug (DMARD) of when treating RA. DMARDS should slow the growth of disease and multiple studies confirmed the strength of MTX in doing so. Unfortunately, competitive with this drug may be, there was still many cases when patients may not respond as well as hoped or they will sustain unwanted effects that limited using the drug.
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